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储建林
阅读次数:     发布时间:2023-05-24

 

储建林,副教授,硕士生导师。

2018年获中国商业联合会科学技术奖(全国商业科技进步奖二等奖)1项,2019年获5060全讯白菜网本科生优秀毕业设计(论文)优秀指导教师奖和“5060全讯白菜网优秀班主任”称号。

主要教育和工作经历:

2017/04-至今,5060全讯白菜网,白菜网所有网站大全,讲师

2014/09-2017/03,5060全讯白菜网,博士后

2009/09-2014/06,5060全讯白菜网,药物化学/生物化工,博士

2005/09-2009/06,5060全讯白菜网,制药工程,学士

研究方向和研究领域:

主要研究方向为微生物与生化药学、合成生物学、绿色生物制造。从事于生物制药涉及的分子生物学、计算生物学、蛋白质工程、分子酶工程等领域的研究,包括极端微生物菌种筛选与高效酶类基因的发掘、蛋白药物的设计与高效表达、酶分子设计与进化改造和计算模拟;药用多糖产生菌的发酵与调控;重要糖苷类天然产物和糖类药物的生物合成;以及非水相生物催化技术、多酶催化/固定化多酶催化天然产物的改造与生物合成等方面的研究。

研究成果:

已发表SCIE/IE收录论文30余篇和国内期刊论文近10篇。参与申请国际和国家发明专利20多项,其中已获得授权的国家发明专利10多项以及2项国际发明专利(PCT)已获多国授权。主持国家自然科学基金青年基金项目一项,江苏省自然科学基金面上项目一项和江苏省高校自然科学研究面上项目各一项。主持并完成中国博士后科学基金面上项目(一等资助)和江苏省博士后科研资助计划项目各一项。以项目主要成员参与国家自然科学基金项目4项、教育部高等学校博士学科点专项科研基金项目(优先发展领域)1项、江苏省高校自然科学研究重大项目1项和江苏省自然科学基金项目2项等项目的研究。目前,参与在研国家重点研发计划项目子课题1项。

发表的部分论文(*通讯作者):

1. Jianlin Chu, Yani Tian, Qian Li, Gaofei Liu, Qi Yu, Tianyue Jiang*, Bingfang He*. Engineering the β-Fructofuranosidase Fru6 with Promoted Transfructosylating Capacity for Fructooligosaccharide Production. J. Agric. Food Chem., 2022, 70(31): 9694-9702.

2. Yuqiu Wang, Huihui Lu, Maoze Guo, Jianlin Chu*, Bingbing Gao*, Bingfang He. Personalized and Programmable Microneedle Dressing for Promoting Wound Healing. Adv. Healthcare Mater., 2022, 11(2): 2101659.

3. Lu Zhao, Xiaoli Xu, Yani Tian, Bailu Pang, Jianlin Chu*, Bingfang He*. Single site mutations of glycosyltransferase with improved activity and regioselectivity for directed biosynthesis of unnatural protopanaxatriol-type ginsenoside product. Molecular Catalysis, 2021, 515: 111937.

4. Gaofei Liu, Xin Tong, Jialing Wang, Bin Wu, Jianlin Chu*, Yongchan Jian, Bingfang He*. Reshaping the binding pocket of purine nucleoside phosphorylase for improved production of 2-halogenated-2'-deoxyadenosine. Catalysis Science & Technology, 2021, 11:4439-4446.

5. Anni Li, Cheng Cheng, Weimin Qi, Xin Pan, Xuanping Xu, Xinyu Wang, Chunying Wu, Jianlin Chu*, Bingfang He*. Combing multiple site-directed mutagenesis of penicillin G acylase from Achromobacter xylosoxidans PX02 with improved catalytic properties for cefamandole synthesis. Int. J. Biol. Macromol., 2021, 175: 322-329.

6. Jingxuan Zhang, BingbingGao, KaiLv, Lot Kumissay, Bin Wu, Jianlin Chu*, Bingfang He*. Specific immobilization of lipase on functionalized 3D printing scaffolds via enhanced hydrophobic interaction for efficient resolution of racemic 1-indanol. Biochem. Bioph. Res. Co., 2021, 546:111-117.

7. Jianlin Chu, Jiheng Yue, Song Qin, Yuqiang Li, Bin Wu* and Bingfang He*. Biocatalysis for Rare Ginsenoside Rh2 Production in High Level with Co-Immobilized UDP-Glycosyltransferase Bs-YjiC Mutant and Sucrose Synthase AtSuSy. Catalysts, 2021,11(1):132.

8. Yuqiang Li, Bingfeng Li, Tianyi Chen, Bin Wu, Jianlin Chu*, Bingfang He*. Exploiting the Reversibility of GTBP1 Catalyzed One-pot Reactions for the Synergistical Synthesis of Ponasterone A and Phenolic Glycosides. Biotechnology and Bioprocess Engineering, 2021, 26:408-418.

9. Xin Pan, Anni Li, Zhiyi Peng, Xiaoqi Ji, Jianlin Chu*, Bingfang He*.Efficient synthesis of β-lactam antibiotics with in situ product removal by a newly isolated penicillin G acylase. Bioorganic Chemistry, 2020, 99:103765.

10. Tianshu Chu#, Jianlin Chu#, Bingbing Gao*, Bingfang He. Modern evolution of paper-based analytical devices for wearable use: from disorder to order. Analyst, 2020, 145:5388-5399.

11. Gaofei Liu, Tiantong Cheng, Jianlin Chu*, Sui Li, Bingfang He*. Efficient Synthesis of Purine Nucleoside Analogs by a New Trimeric Purine Nucleoside Phosphorylase from Aneurinibacillus migulanus AM007. Molecules, 2020, 25(1):100.

12. Bo Fan, Wenxin Dong, Tianyi Chen, Jianlin Chu*, Bingfang He*. Switching glycosyltransferase UGTBL1 regioselectivity toward polydatin synthesis using a semi-rational design. Organic & Biomolecular Chemistry, 2018, 16:2464-2469.

参与的获授权国际和国家发明专利(部分)

1Bingfang He, Xueming Wu, Jianlin Chu, et al. Fructosylated mangiferin and preparation method therefor and use thereof. 国际发明专利(PCT)公开号:WO2013/004086A1;中国授权号:ZL 201110188224.6;美国授权号:US 8, 946,407B2; 欧盟授权号:EP2657245; 韩国授权号:10-1653586.

2Bingfang He, Xueming Wu, Jianlin Chuet al. Fructosylated puerarin and preparation method and use thereof. 国际发明专利(PCT)公开号:WO2012/048522A1;中国授权号:ZL 201110119350.6;欧盟授权号:EP 2615100;日本授权号: 5671622; 美国授权号:US 8, 598, 128B2;韩国授权号:10-1622915.

3、何冰芳,徐晓丽,储建林 等;糖基转移酶突变体在定向合成非天然人参皂苷中的应用,授权号:ZL 202210627522.9

4、何冰芳,李安妮,储建林,吴斌 等;青霉素G酰化酶突变体及其在酶法合成头孢孟多中的应用,授权号:ZL 202010488868.6

5、何冰芳,叶家捷储建林吴斌;一种耐有机溶剂高效半乳糖苷酶及其应用,授权号:ZL 201810196588.0

6何冰芳余棋储建林吴斌姜天玥;β-呋喃果糖苷酶突变体及其应用,授权号:ZL 201810405006.5

7、何冰芳,周有治,储建林 等;一株耐有机溶剂高效转糖基β-半乳糖苷酶高产菌株以及该半乳糖苷酶的基因和应用,授权号:ZL201510315786.0

8、何冰芳,周有治,储建林 等;一种耐有机溶剂半乳糖苷酶高产菌以及该半乳糖苷酶的基因和应用,授权号:ZL 201510313195.X

E-mail: cjl2fl@njtech.edu.cn